PTPN6 polyclonal antibody
产品名称： PTPN6 polyclonal antibody
英文名称： PTPN6 polyclonal antibody
产品编号： PAB7248
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of PTPN6.
- Immunogen:
- A synthetic peptide corresponding to human PTPN6.
- Sequence:
- C-KASRTSSKHKEE
- Host:
- Goat
- Theoretical MW (kDa):
- 67.6, 67.7
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is expected to recognize both reported isoforms (NP_536858.1and NP_002822.2). Please note this antibody was designed using the mouse sequence, which differs by 1 amino acid from the human sequence.
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:128000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournes B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A.Nat Med. 2006 May;12(5):549-56. Epub 2006 Apr 16.
- Entrez GeneID:
- 5777
- Protein Accession#:
- NP_536858.1;NP_002822.2
- Gene Name:
- PTPN6
- Gene Alias:
- HCP,HCPH,HPTP1C,PTP-1C,SH-PTP1,SHP-1,SHP-1L,SHP1
- Gene Description:
- protein tyrosine phosphatase, non-receptor type 6
- Omim ID:
- 176883
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
- Other Designations:
- hematopoietic cell phosphatase,hematopoietic cell protein-tyrosine phosphatase,protein-tyrosine phosphatase 1C